Niclosamide

Common name niclosamide (BSI, E-ISO, (m) F-ISO, BAN, Germany (for veterinary use))

IUPAC name 2',5-dichloro-4'-nitrosalicylanilide 

Chemical Abstracts name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide 

CAS RN [50-65-7]

Mol. wt. 327.1 

M.f. C13H8Cl2N2O4 

Form Almost colourless crystals. 

M.p. 230 篊 

V.p. <1 mPa (20 篊) 

KOW logP = 1 (pH 9.6) 

Solubility In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/l, 20 篊). Soluble in common organic solvents such as ethanol and diethyl ether.

niclosamide-olamine

Common name niclosamide-olamine (BSI, E-ISO, (m) F-ISO, BAN); clonitralid (Germany, for public health use)

CAS RN [1420-04-8]

Mol. wt. 388.2 

M.f. C15H15Cl2N3O5 

Form Yellow, crystalline solid. 

M.p. Decomposes at 208 篊 

V.p. <<1 mPa (20 癈) 

Solubility In water 0.1 g/l (20 篊). In n-hexane, toluene <0.1, dichloromethane 0.015, isopropanol 0.25 (all in g/l, 20 篊). 

Mode of action Molluscicide with respiratory and stomach action. 

Uses Control of golden apple snail in rice.